Low dose oral administration of monosodium glutamate in male albino rats may be nephroprotective

The speculation that low dose intake of monosodium glutamate over time may be toxic warranted the present study. The aim was to investigate the effect of the administration of monosodium glutamate at a low concentration on the function…

  ACC Egbuonu, O Obidoa, CA Ezeokonkwo, LU Ezeanyika, PM Ejikeme

 Vol.7  No.1 - 2009
Status:  Published

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Preformulation compatibility screening of dika fat-drug mixtures using differential scanning calorimetry

Differential scanning calorimetry (DSC) was used as screening technique for assessing compatibility between dika fat and drug substances. Dika fat was found to be compatible with aspirin, ascorbic acid, paracetamol, sulphanilamide, phe…

  JO Onyechi

 Vol.7  No.1 - 2009
Status:  Published

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In-vitro evaluation of bioadhesive and release properties of thiamine hydrochloride formulation from Gelatin, Gellan as their admixtures

This study was aimed at determining the effect of gelatin on the bioadhesive strength and release properties of gelatin gum. Bioadhesive strength determination was carried out using tensiometric methods. Thiamine tablets was prepared b…

  MA Momoh, MU Adikwu, UE Nwachi, AA Attama, T Gugu

 Vol.7  No.1 - 2009
Status:  Published

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Use of dika fat in the formulation of sustained release theophylline tablets and capsules

Sustained release theophylline tablets and capsules were prepared with dika fat, a solid vegetable oil extracted from the kernels of Irvingia gabonesis var gabonesis and var excelsia. Anhydrous theophylline was incorporated into dika f…

  GC Umekoli, JO Onyechi, OK Udeala

 Vol.7  No.1 - 2009
Status:  Published

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Anti-ulcer activity of the leaf extracts of Borreria ocymoides in rats

The anti-ulcer properties of the leaf extracts of Borreria ocymoides Burm. F. (Rubiaceae) was investigated. Sixty (60) albino rats of either sex weighing 160-216g and fifteen (15) albino mice weighing 25-36 g were used for the study. S…

  CN Okwuosa, DC Nwachukwu, PUO Achukwu, CG Ezeorah, AA Eze

 Vol.7  No.1 - 2009
Status:  Published

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Effects of phenobarbital administration on the histology of the liver and brain, and the activities of some biochemical parameters of the liver of Wister rats

The effects of phenobarbital on the histology of the liver and the brain and on selected biochemical parameters of the liver of wistar rats were studied. Histological examination showed prominent lesions in the liver and brain of the t…

  AA Eze, DC Nwaohukwu, PU Achukwu, CN Okwuosa

 Vol.7  No.1 - 2009
Status:  Published

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In-Vitro antibacterial activity of bioactive plant extracts against methicillin-resistant strains of staphylococcus aureus

Methanol extract of leaves of five different Nigerian plants were tested for activity against three drug resistant strains of Staphylococcus aureus by the agar well diffusion and broth microdilution techniques. The S. aureus strains we…

  EA Eze, CO Nwuche, AM Ugwu

 Vol.7  No.1 - 2009
Status:  Published

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 Vol.7  No.1 - 2009
Status:  Published

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Co-infection and morphometrics of three clinostomatids (Digenea: Clinostomatidae) in Tilapia guinensis Bleeker, 1862 from Opi lake, Nigeria

Co-infection and morphometrics of helminth parasites of Tilapia guinensis in Opi Lake (GPS N06.75275*, E007.49104*), were studied from (Nov 2007– Oct 2008) using multiple fishing gear techniques; cast nets, hook and line, and seine net…

  PC Echi, FC Okafor, JE Eyo

 Vol.7  No.1 - 2009
Status:  Published

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The effect of cosolvents and surfactants on the aqueous solubility of Irbesartan

It was considered an interest to enhance the aqueous solubility of irbesartan. To accomplish this objective, the solubilization of irbesartan by cosolvency and micellization was investigated. It was found that all the cosolvents (ethan…

  CJ Mbah, CM Eneasato

 Vol.7  No.1 - 2009
Status:  Published

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