Methanol extract of leaves of five different Nigerian plants were tested for activity against three drug resistant strains of Staphylococcus aureus by the agar well diffusion and broth microdilution techniques. The S. aureus strains were composed of two clinical isolates and one reference strain. Promising antimicrobial activity was displayed by three of the five plants tested. Minimum inhibitory concentration (MIC) of the extracts ranged from 25 mg/ml to 100 mg/ml. The clinical isolates had comparable level of sensitivity to the three most active extracts. Both were also more susceptible to the extracts than the reference strain. Phytochemical analyses showed that secondary plant constituents were present in varied concentrations in all the extracts.
EA Eze, CO Nwuche, AM Ugwu
