Hot-water infusion of the leaf of Ocimum gratissimum was tested for anti-diarrhoeal action using animal models. Protection of the animals from castor oil-induced diarrhoea and reduction of the number and frequency of faecal output were used as criteria for anti-diarrhoeal activity. The infusion significantly decreased the number of faecal droppings as compared to a normal saline control; it also reduced the propulsive movement of the gastrointestinal contents. The infusion caused a reduction of acetylcholine-induced contraction of isolated guinea pig ileum in a dose dependent manner. There is indication that the anti-diarrhoeal action of the plant infusion may be due to a blockage of muscarinic receptors.
VC Okore, CI Asogwa, PO Nnamani
