Evaluation of Antibacterial Activity and Interaction of Methanolic Extract of Physcia grisea and Cephalosporin on Clinical Isolates of Streptococcus pyogenes

This study was carried out to investigate the antibacterial activity and interaction of methanolic extract of Physcia grisea and cephalosporin on the clinical isolates of Streptococcus pyogenes. The isolates of S. pyogenes used were obtained from the department of Pharmaceutical microbiology, University of Nigeria, Nsukka. The sensitivity pattern of these isolates to P. grisea extract, cephalosporin and P. grisea extract combined with cephalosporin was carried out using agar diffusion technique. The result of the in vitro study showed that the MIC of P. grisea extract was decreased by cephalosporin thereby increasing its efficacy. The test micro-organism, S. pyogenes was highly sensitive to P. grisea combined with cephalosporin, but moderately sensitive to P. grisea extract. This shows that in the treatment of streptococcal infections caused by S. pyogenes, combined P. grisea, extract and cephalosporin may give the best therapeutic effect.

 EI Eze, VN Onumah