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Effect of Larimal on the Astrocytes of the Cerebellum of Wistar Rats

Larimal® is an artemisinin-base antimalaria made up of artesunate and amodiaquine. It is very effective in combating malaria caused by Plasmodium falciparum. This study was to assess the effect of the drug on the astrocytes of the cerebellum of Wistar rats. Twenty adult Wistar rats weighing between 160-180g were equally assigned into four groups (A, B, C and D). Group A served as the control that received distilled water, while groups B, C and D received 17.50±5.71mg/kg, 8.75±2.86mg/kg and 8.75±2.86mg/kg body weights of Larimal® respectively. Groups B and C were given the drug for three days, and group D for six days. The treatment was twelve hourly, and twelve hours after the last administration the animals were sacrificed. There were hyperplasia and hypertrophy of astrocytes in all the experimental groups, and these were more pronounced in group B. These results revealed that Larimal® caused reactive astrocytes in the cerebellum of Wistar rats and these were dose and time dependent.

1Ekong, M. B., 2Igiri, A. O., 3Salami, E. and 4Egwu, O. A. IDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo-Nigeria 2Department of Anatomy, Faculty of Basic Medical Sciences, College of Medical

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