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Evaluation of Plasma Electrolyte Concentration in Pregnant Nigerian Women From Edo State, Nigeria

The renal function status in relation to electrolyte homeostasis was evaluated in a total of one hundred pregnant Nigerian women (volunteers) and thirty non-pregnant controls. The volunteers were of varying maternal age, parity, trimester, weight, height, and social status while the non-pregnant women were of approximate age to serve as control. Analysis of the results revealed that sodium (136.21±0.39mmol/l), potassium (3.69±0.004mmol/l), calcium (2.17 ± 0.02mmol/l), and bicarbonate (20.39 ± 0.26mmol/l) were significantly reduced (P<0.05) when compared to the control (137.97±0.46mmol/l, 4.29±0.09mmol/l, 2.59±0.03mmol/l and 25.87±0.43mmol/l respectively). There was a significant decrease (P<0.05) in sodium, potassium, calcium and bicarbonate concentrations as pregnancy progressed. Maternal age is positively correlated with sodium (r=0.092) and potassium (r=0.100) but inversely correlated with calcium (r=-0.088) and bicarbonate (r=-0.051) concentrations. While parity is inversely correlated with sodium (r=-0.045), potassium (r=-0.155) and calcium (r=-0.175), it was positively correlated with bicarbonate (r=0.015) concentrations. All the electrolytes have positive correlation with gestation (Na+: r=0.249, K+: r=0.204, Ca2+: r=0.004 and HCO3-: r=0.056) while social status was inversely correlated to all the parameters (Na+: r=-0.151, K+: r=-0.075, Ca2+: r=-0.046 and HCO3-: r=0.023;P<0.05). Nutrition, environmental condition and child’s spacing may have influenced the parameters and their implications with respect to proper fetal development are discussed.
 

1Onyeneke, E.C., 1Anekwe, A.I., 1Okoro, S.J., 2Anionye, J.C. and 3Onovughakpo-Sakpa, O.E. 1Department of Biochemistry, 2Department of Medical Biochemistry and 3Department of Chemical Pathology, University of Benin, Benin City, Edo State, Nigeria.

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